General theory of genotype to phenotype mapping: derivation of epigenetic landscapes from N-node complex gene regulatory networks.
نویسندگان
چکیده
We propose a systematic methodology to construct a probabilistic epigenetic landscape of cell-fate attainment associated with N-node Boolean genetic regulatory networks. The general derivation proposed here is exemplified with an Arabidopsis thaliana network underlying floral organ determination grounded on qualitative experimental data.
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عنوان ژورنال:
- Physical review letters
دوره 109 11 شماره
صفحات -
تاریخ انتشار 2012